Long term improvement of glucose homeostasis by vanadate in obese hyperinsulinemic fa/fa rats.

摘要: The trace element vanadium (V) exerts insulin-like effects in vitro and lowers blood glucose streptozotocin-diabetic rats. present study examined whether V can also improve homeostasis genetically obese, insulin-resistant Na3VO4 was administered for 3 months water food to Zucker fa/fa Since these rats reduced their intake by about 30% compared controls (C), one group of untreated pair-fed (P-F) with In the fed state, insulin/glucose ratio lower than P-F or C rats, merely because a decrease (approximately 50%) plasma insulin levels. Tolerance oral improved only; integrated response that Insulin levels were but not consistently decreased. During an iv tolerance test, disappearance rate 50% higher other two groups. An arginine test clearly showed B-cell responsiveness increased sensitivity, assessed insulin-induced hypoglycemia, similar slightly better conclusion, vanadate produces sustained improvement insulin-like, largely body weight-independent mechanism