A review of high shear wet granulation for better process understanding, control and product development
作者： Binbin Liu , Jiamiao Wang , Jia Zeng , Lijie Zhao , Youjie Wang
DOI: 10.1016/J.POWTEC.2020.11.051
关键词:
摘要: Abstract High shear wet granulation (HSWG) is considered a complicated and multivariate pharmaceutical process that influenced by large number of variables derived from equipment, formulations, processes. A better understanding effective control the are required to achieve desired attributes final target products improve efficiency product development. This review provides comprehensive introduction improvement HSWG-based development, including mechanism, factors affecting process, in-line monitoring technologies, modeling methods for HSWG process. We also discuss application quality design in control, especially its two important tools, risk management experience. Additionally, some potential problems challenges current research analyzed highlighted. The main purpose provide guidance formulation scientists understand then
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