Sequential Signaling through Notch1 and erbB Receptors Mediates Radial Glia Differentiation

摘要: Radial glia cells both generate neurons and physically guide nascent to their target destination in the cortex, as such they are essential for CNS development. It has been proposed that developing cerebellum, neuronal contact induces radial formation, however, mechanisms involved this process not well understood. Here we demonstrate induction of formation is result sequential signaling through Notch1 erbB receptors. First, activation by glial expression brain lipid binding protein (BLBP) erbB2 genes. Interestingly, two different pathways mediate these effects on transcription, BLBP being dependent Su(H), whereas regulated a yet unidentified pathway. The subsequent increase receptor makes more responsive NRG, which then morphological transformation into glia. Thus, results unveil some underlying formation.