Mitoproteome plasticity of rat brown adipocytes in response to cold acclimation
作者： Rachel Navet , Gregory Mathy , Pierre Douette , Rowan Laura Dobson , Pierre Leprince
DOI: 10.1021/PR060064U
关键词:
摘要: Cold acclimation induces an adaptative increase in respiration brown adipose tissue (BAT). A comparative analysis by two-dimensional differential in-gel electrophoresis of mitochondrial protein patterns found rat control and cold-acclimated BAT was performed. total 58 proteins exhibiting significant differences their abundance unambiguously identified. Proteins implicated the major catabolic pathways were up-regulated as ATP synthase mitofilin. Moreover, these results support fact that adipocytes can balance synthesis heat production linked to UCP1-sustained uncoupling.
core.ac.uk
acs.org
sci-hub.se 参考文章(26)
L Grinblat, L F Pacheco Bolaños, A O Stoppani, Decreased rate of ketone-body oxidation and decreased activity of D-3-hydroxybutyrate dehydrogenase and succinyl-CoA:3-oxo-acid CoA-transferase in heart mitochondria of diabetic rats. Biochemical Journal. ,vol. 240, pp. 49- 56 ,(1986) , 10.1042/BJ2400049
David G. Nicholls, Eduardo Rial, A history of the first uncoupling protein, UCP1. Journal of Bioenergetics and Biomembranes. ,vol. 31, pp. 399- 406 ,(1999) , 10.1023/A:1005436121005
D G Nicholls, R M Locke, Thermogenic mechanisms in brown fat. Physiological Reviews. ,vol. 64, pp. 1- 64 ,(1984) , 10.1152/PHYSREV.1984.64.1.1
J.A. Jaskiewicz, R.A. Harris, N.Y. Kedishvili, K.M. Popov, Coordinated Expression of Valine Catabolic Enzymes During Adipogenesis: Analysis of Activity, mRNA, Protein Levels, and Metabolic Consequences Archives of Biochemistry and Biophysics. ,vol. 315, pp. 317- 322 ,(1994) , 10.1006/ABBI.1994.1506
Michael. Karas, Franz. Hillenkamp, Laser desorption ionization of proteins with molecular masses exceeding 10,000 daltons Analytical Chemistry. ,vol. 60, pp. 2299- 2301 ,(1988) , 10.1021/AC00171A028
Simon Eaton, Control of mitochondrial beta-oxidation flux. Progress in Lipid Research. ,vol. 41, pp. 197- 239 ,(2002) , 10.1016/S0163-7827(01)00024-8
Wieslawa Jarmuszkiewicz, Claudine M Sluse-Goffart, Lilla Hryniewiecka, Francis E Sluse, None, Identification and Characterization of a Protozoan Uncoupling Protein in Acanthamoeba castellanii Journal of Biological Chemistry. ,vol. 274, pp. 23198- 23202 ,(1999) , 10.1074/JBC.274.33.23198
Leanne Wilson-Fritch, Sarah Nicoloro, My Chouinard, Mitchell A. Lazar, Patricia C. Chui, John Leszyk, Juerg Straubhaar, Michael P. Czech, Silvia Corvera, Mitochondrial remodeling in adipose tissue associated with obesity and treatment with rosiglitazone Journal of Clinical Investigation. ,vol. 114, pp. 1281- 1289 ,(2004) , 10.1172/JCI21752
Angel A. Zaninovich, Marcela Raíces, Inés Rebagliati, Conrado Ricci, Karl Hagmüller, Brown fat thermogenesis in cold-acclimated rats is not abolished by the suppression of thyroid function. American Journal of Physiology-endocrinology and Metabolism. ,vol. 283, ,(2002) , 10.1152/AJPENDO.00540.2001
Wiesława Jarmuszkiewicz, Graziela Milani, Fabiane Fortes, Angelica Z. Schreiber, Francis E. Sluse, Anibal E. Vercesi, First evidence and characterization of an uncoupling protein in fungi kingdom: CpUCP of Candida parapsilosis web science. ,vol. 467, pp. 145- 149 ,(2000) , 10.1016/S0014-5793(00)01138-8