New pathological findings in amyotrophic lateral sclerosis

摘要: There have been recent developments in the pathology of sporadic ALS. A new filamentous neuronal inclusion body ALS detected by immunohistochemical localisation protein ubiquitin has characterised at light microscopic and ultrastructural level appears specific for disease. The molecular composition underlying filaments remains unresolved but quest this is a major aim research. Despite being progressive degenerative process which primarily affects motor systems, now recognised to involve several non-motor systems long survivors many subcortical structures. also accumulating evidence that neurodegenerative may present as clinical syndrome, particularly frontal lobe dementia with characteristic inclusions cortex. Considering multisystem disease rather than simply neurones implications research into pathogenesis.