Characteristics of β-phenethylamine self-administration by dog
作者： Marc E. Risner , B.E. Jones
DOI: 10.1016/0091-3057(77)90096-X
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摘要: Abstract Phenethylamine (PEA), a biologically active amine found in the brain, maintained intravenous self-administration behavior by dogs previously trained to respond for amphetamine. Systematic changes unit dose of PEA (1.5 6.0 mg/kg/infusion) were negatively related number infusions (91.3 29.5, respectively) per 4 hr session. The mean intake was 165 mg/kg/session. Pretreatment with chlorpromazine (0.5 2.0 mg/kg, IV, 30 min prior session) produced dose-dependent increase self-administered infusions. However, there no responding following pretreatment either dopaminergic antagonist pimozide (5 40 μg/kg, or adrenergic phenoxybenzamine (1 8 session). These data suggest that reinforcing properties are not dependent on system.
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sci-hub.se 参考文章(23)
John G. Wagner, Fundamentals of Clinical Pharmacokinetics ,(1975)
E. E. Inwang, A. D. Mosnaim, H. C. Sabelli, Isolation and characterization of phenylethylamine and phenylethanolamine from human brain. Journal of Neurochemistry. ,vol. 20, pp. 1469- 1473 ,(1973) , 10.1111/J.1471-4159.1973.TB00259.X
K. Fuxe, H. Grobecker, J. Jonsson, The effect of β-phenylethylamine on central and peripheral monoamine-containing neurons European Journal of Pharmacology. ,vol. 2, pp. 202- 207 ,(1967) , 10.1016/0014-2999(67)90088-X
Sven Ahlenius, Jörgen Engel, On the interaction between pimozide and alpha-methyltyrosine. Journal of Pharmacy and Pharmacology. ,vol. 25, pp. 172- 174 ,(2011) , 10.1111/J.2042-7158.1973.TB10615.X
Marc E. Risner, Intravenous self-administration of d- and l-amphetamine by dog. European Journal of Pharmacology. ,vol. 32, pp. 344- 348 ,(1975) , 10.1016/0014-2999(75)90302-7
William J. Giardina, Walter A. Pedemonte, Hector C. Sabelli, Iontophoretic study of the effects of norepinephrine and 2-phenylethylamine on single cortical neurons Life Sciences. ,vol. 12, pp. 153- 161 ,(1973) , 10.1016/0024-3205(73)90129-X
Marc E. Risner, B. E. Jones, Self-administration of CNS stimulants by dog. Psychopharmacology. ,vol. 43, pp. 207- 213 ,(1975) , 10.1007/BF00429252
P. H. Wu, Alan A. Boulton, Metabolism, Distribution, and Disappearance of Infected β-Phenylethylamine in the Rat Biochemistry and Cell Biology. ,vol. 53, pp. 42- 50 ,(1975) , 10.1139/O75-007
R. Yokel, R. Wise, Increased lever pressing for amphetamine after pimozide in rats: implications for a dopamine theory of reward. Science. ,vol. 187, pp. 547- 549 ,(1975) , 10.1126/SCIENCE.1114313
H. C. Sabelli, A. J. Vazquez, D. Flavin, Behavioral and electrophysiological effects of phenylethanolamine and 2-phenylethylamine. Psychopharmacology. ,vol. 42, pp. 117- 125 ,(1975) , 10.1007/BF00429541