Pepsin, a marker of gastric contents, is increased in tracheal aspirates from preterm infants who develop bronchopulmonary dysplasia.
作者： S. Farhath , Z. He , T. Nakhla , J. Saslow , S. Soundar
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摘要: OBJECTIVE. The objective of this study was to the association between pepsin in tracheal aspirate samples and development bronchopulmonary dysplasia preterm infants. METHODS. Serial were collected during first 28 days from mechanically ventilated neonates. Bronchopulmonary defined as need for supplemental oxygen at 36 weeks’ postmenstrual age. An enzymatic assay with a fluorescent substrate used detect pepsin. Total protein measured by Bradford correct dilution lavage. Immunohistochemistry using antibody against human pepsinogen performed 10 lung tissue RESULTS. A total 256 59 Pepsin detected 234 (91.4%) samples. Twelve infants had no dysplasia, 31 developed 16 died before mean concentration significantly lower compared those who or dysplasia/died Moreover, level higher severe moderate dysplasia. 7 also Pepsinogen not localized tissues immunohistochemistry. CONCLUSION. increased Recovery is secondary gastric aspiration, hematogenous spread local synthesis lungs. Chronic aspiration contents may contribute pathogenesis
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