Lipids and flaviviruses, present and future perspectives for the control of dengue, Zika, and West Nile viruses.

摘要: Flaviviruses are emerging arthropod-borne pathogens that cause life-threatening diseases such as yellow fever, dengue, West Nile encephalitis, tick-borne Kyasanur Forest disease, or Zika disease. This viral genus groups >50 species of small enveloped plus strand RNA virus phylogenetically closely related to hepatitis C virus. Importantly, the flavivirus life cycle is intimately associated host cell lipids. Along this line, flaviviruses rearrange intracellular membranes from endoplasmic-reticulum infected cells develop adequate platforms for replication and particle biogenesis. Moreover, dramatically orchestrate a profound reorganization lipid metabolism create favorable environment multiplication. Consistently, recent work has shown importance specific classes in infections. For instances, fatty acid synthesis linked replication, phosphatidylserine phosphatidylethanolamine involved on entry flaviviruses, sphingolipids (ceramide sphingomyelin) play key role assembly pathogenesis, cholesterol essential innate immunity evasion flavivirus-infected cells. Here, we revise current knowledge interactions with cellular identify potential targets future antiviral development aimed combat these relevant health-threatening pathogens.