Differential utilisation of ceramide during replication of the flaviviruses West Nile and dengue virus.
作者： Turgut E. Aktepe , Helen Pham , Jason M. Mackenzie
DOI: 10.1016/J.VIROL.2015.06.015
关键词:
摘要: It is well established that +ssRNA viruses manipulate cellular lipid homoeostasis and distribution to facilitate efficient replication. Here, we show the ceramide redistributed West Nile virus strain Kunjin (WNVKUN) replication complex (RC) but not dengue serotype 2 New Guinea C (DENVNGC) RC. We prolonged chemical inhibition of serine palmitoyltransferase with myriocin had a significant deleterious effect on WNVKUN enhanced DENVNGC Additionally, synthase Fumonisin B1 detrimental release infectious particles contrastingly an enhancing production. These observations suggest production via de novo salvage pathway requirement for inhibitory Thus, although these two are from same genus, they have differential
sci-hub.se 参考文章(46)
E. Wang, W.P. Norred, C.W. Bacon, R.T. Riley, A.H. Merrill, Inhibition of sphingolipid biosynthesis by fumonisins. Implications for diseases associated with Fusarium moniliforme. Journal of Biological Chemistry. ,vol. 266, pp. 14486- 14490 ,(1991) , 10.1016/S0021-9258(18)98712-0
Jason M. Mackenzie, Malcolm K. Jones, Edwin G. Westaway, Markers for trans-Golgi Membranes and the Intermediate Compartment Localize to Induced Membranes with Distinct Replication Functions in Flavivirus-Infected Cells Journal of Virology. ,vol. 73, pp. 9555- 9567 ,(1999) , 10.1128/JVI.73.11.9555-9567.1999
Rajesh Shinghal, Richard H. Scheller, Sandra M. Bajjalieh, Ceramide 1-Phosphate Phosphatase Activity in Brain Journal of Neurochemistry. ,vol. 61, pp. 2279- 2285 ,(1993) , 10.1111/J.1471-4159.1993.TB07470.X
Yusuf A. Hannun, Lina M. Obeid, Principles of bioactive lipid signalling: lessons from sphingolipids Nature Reviews Molecular Cell Biology. ,vol. 9, pp. 139- 150 ,(2008) , 10.1038/NRM2329
Carmen Garcia-Ruiz, Albert Morales, José C. Fernández-Checa, Glycosphingolipids and cell death: one aim, many ways Apoptosis. ,vol. 20, pp. 607- 620 ,(2015) , 10.1007/S10495-015-1092-6
Jiraphan Junjhon, Janice G Pennington, Thomas J Edwards, Rushika Perera, Jason Lanman, Richard J Kuhn, None, Ultrastructural Characterization and Three-Dimensional Architecture of Replication Sites in Dengue Virus-Infected Mosquito Cells Journal of Virology. ,vol. 88, pp. 4687- 4697 ,(2014) , 10.1128/JVI.00118-14
Rubén Soto-Acosta, Clemente Mosso, Margot Cervantes-Salazar, Henry Puerta-Guardo, Fernando Medina, Liliana Favari, Juan E. Ludert, Rosa María del Angel, The increase in cholesterol levels at early stages after dengue virus infection correlates with an augment in LDL particle uptake and HMG-CoA reductase activity Virology. ,vol. 442, pp. 132- 147 ,(2013) , 10.1016/J.VIROL.2013.04.003
Olaf Utermöhlen, Jasmin Herz, Michael Schramm, Martin Krönke, Fusogenicity of membranes: the impact of acid sphingomyelinase on innate immune responses. Immunobiology. ,vol. 213, pp. 307- 314 ,(2008) , 10.1016/J.IMBIO.2007.10.016
Xavier Nirmala, Marc F. Schetelig, Grazyna J. Zimowska, Lei Zhou, Alfred M. Handler, Pro-apoptotic gene regulation and its activation by gamma-irradiation in the Caribbean fruit fly, Anastrepha suspensa Apoptosis. ,vol. 20, pp. 1- 9 ,(2015) , 10.1007/S10495-014-1055-3
Martin Krönke, Biophysics of ceramide signaling: interaction with proteins and phase transition of membranes. Chemistry and Physics of Lipids. ,vol. 101, pp. 109- 121 ,(1999) , 10.1016/S0009-3084(99)00059-6