Comparative assessment of transmission-blocking vaccine candidates against Plasmodium falciparum.
作者： MC Kapulu , DF Da , K Miura , Y Li , AM Blagborough
DOI: 10.1038/SREP11193
关键词:
摘要: Malaria transmission-blocking vaccines (TBVs) target the development of Plasmodium parasites within mosquito, with aim preventing malaria transmission from one infected individual to another. Different vaccine platforms, mainly protein-in-adjuvant formulations delivering leading candidate antigens, have been developed independently and reported varied activities (TBA). Here, recombinant chimpanzee adenovirus 63, ChAd63, modified vaccinia virus Ankara, MVA, expressing AgAPN1, Pfs230-C, Pfs25, Pfs48/45 were generated. Antibody responses primed individually against all antigens by ChAd63 immunization in BALB/c mice boosted administration MVA same antigen. These antibodies exhibited a hierarchy inhibitory activity NF54 laboratory strain P. falciparum Anopheles stephensi mosquitoes using standard membrane feeding assay (SMFA), anti-Pfs230-C anti-Pfs25 giving complete blockade. The observed rank order inhibition was replicated African field isolates A. gambiae direct assays (DMFA). TBA achieved IgG concentration dependent. This study provides first head-to-head comparative analysis two different parasite sources vector species, can be used guide selection TBVs for future clinical viral-vectored delivery platform.
nature.com
core.ac.uk
harvard.edu
jenner.ac.uk
imperial.ac.uk参考文章(66)
Ananias A. Escalante, Francisco J. Ayala, Altaf A. Lal, Genetic Polymorphism and Natural Selection in the Malaria Parasite Plasmodium falciparum Genetics. ,vol. 149, pp. 189- 202 ,(1998) , 10.1093/GENETICS/149.1.189
G. Galli, D. Medini, E. Borgogni, L. Zedda, M. Bardelli, C. Malzone, S. Nuti, S. Tavarini, C. Sammicheli, A. K. Hilbert, V. Brauer, A. Banzhoff, R. Rappuoli, G. Del Giudice, F. Castellino, Adjuvanted H5N1 vaccine induces early CD4+ T cell response that predicts long-term persistence of protective antibody levels Proceedings of the National Academy of Sciences of the United States of America. ,vol. 106, pp. 3877- 3882 ,(2009) , 10.1073/PNAS.0813390106
Sumi Biswas, Matthew D. J. Dicks, Carole A. Long, Edmond J. Remarque, Loredana Siani, Stefano Colloca, Matthew G. Cottingham, Anthony A. Holder, Sarah C. Gilbert, Adrian V. S. Hill, Simon J. Draper, Transgene optimization, immunogenicity and in vitro efficacy of viral vectored vaccines expressing two alleles of Plasmodium falciparum AMA1. PLOS ONE. ,vol. 6, ,(2011) , 10.1371/JOURNAL.PONE.0020977
Susanne H Sheehy, Christopher JA Duncan, Sean C Elias, Prateek Choudhary, Sumi Biswas, Fenella D Halstead, Katharine A Collins, Nick J Edwards, Alexander D Douglas, Nicholas A Anagnostou, Katie J Ewer, Tom Havelock, Tabitha Mahungu, Carly M Bliss, Kazutoyo Miura, Ian D Poulton, Patrick J Lillie, Richard D Antrobus, Eleanor Berrie, Sarah Moyle, Katherine Gantlett, Stefano Colloca, Riccardo Cortese, Carole A Long, Robert E Sinden, Sarah C Gilbert, Alison M Lawrie, Tom Doherty, Saul N Faust, Alfredo Nicosia, Adrian VS Hill, Simon J Draper, ChAd63-MVA-vectored blood-stage malaria vaccines targeting MSP1 and AMA1: assessment of efficacy against mosquito bite challenge in humans Molecular Therapy. ,vol. 20, pp. 2355- 2368 ,(2012) , 10.1038/MT.2012.223
Debabani Roy Chowdhury, Evelina Angov, Thomas Kariuki, Nirbhay Kumar, A potent malaria transmission blocking vaccine based on codon harmonized full length Pfs48/45 expressed in Escherichia coli. PLOS ONE. ,vol. 4, ,(2009) , 10.1371/JOURNAL.PONE.0006352
Susanne H Sheehy, Christopher JA Duncan, Sean C Elias, Katharine A Collins, Katie J Ewer, Alexandra J Spencer, Andrew R Williams, Fenella D Halstead, Samuel E Moretz, Kazutoyo Miura, Christian Epp, Matthew DJ Dicks, Ian D Poulton, Alison M Lawrie, Eleanor Berrie, Sarah Moyle, Carole A Long, Stefano Colloca, Riccardo Cortese, Sarah C Gilbert, Alfredo Nicosia, Adrian VS Hill, Simon J Draper, Phase Ia Clinical Evaluation of the Plasmodium Falciparum Blood-Stage Antigen MSP1 in ChAd63 and MVA Vaccine Vectors Molecular Therapy. ,vol. 19, pp. 2269- 2276 ,(2011) , 10.1038/MT.2011.176
Adam S. Malin, Kris Huygen, Jean Content, Michael Mackett, Lisa Brandt, Peter Andersen, Steven M. Smith, Hazel M. Dockrell, Vaccinia expression of Mycobacterium tuberculosis-secreted proteins: tissue plasminogen activator signal sequence enhances expression and immunogenicity of M. tuberculosis Ag85. Microbes and Infection. ,vol. 2, pp. 1677- 1685 ,(2000) , 10.1016/S1286-4579(00)01323-X
S. Sridhar, A. Reyes-Sandoval, S. J. Draper, A. C. Moore, S. C. Gilbert, G. P. Gao, J. M. Wilson, A. V. S. Hill, Single-dose protection against Plasmodium berghei by a simian adenovirus vector using a human cytomegalovirus promoter containing intron A. Journal of Virology. ,vol. 82, pp. 3822- 3833 ,(2008) , 10.1128/JVI.02568-07
N. S. Outchkourov, W. Roeffen, A. Kaan, J. Jansen, A. Luty, D. Schuiffel, G. J. van Gemert, M. van de Vegte-Bolmer, R. W. Sauerwein, H. G. Stunnenberg, Correctly folded Pfs48/45 protein of Plasmodium falciparum elicits malaria transmission-blocking immunity in mice Proceedings of the National Academy of Sciences of the United States of America. ,vol. 105, pp. 4301- 4305 ,(2008) , 10.1073/PNAS.0800459105
Kazutoyo Miura, Andrew C. Orcutt, Olga V. Muratova, Louis H. Miller, Allan Saul, Carole A. Long, Development and characterization of a standardized ELISA including a reference serum on each plate to detect antibodies induced by experimental malaria vaccines Vaccine. ,vol. 26, pp. 193- 200 ,(2008) , 10.1016/J.VACCINE.2007.10.064