Spontaneous mitotic recombination in mms8-1, an allele of the CDC9 gene of Saccharomyces cerevisiae.
作者： B A Montelone , S Prakash , L Prakash
DOI: 10.1128/JB.147.2.517-525.1981
关键词:
摘要: The methyl methane sulfonate (MMS)-sensitive mutation mms8-1 increases the rate of spontaneous mitotic intragenic recombination at five heteroallelic loci on three chromosomes. Complementation, segregation, and mapping studies indicate that is allelic to cdc9, known be defective in deoxyribonucleic acid ligase. Both cdc9 mutants are lethal combination with recombination-defective mutant rad52-1. Genetic analysis red/white sectors an ade2-1/ade2-1 ade5/+ mms8-1/mms8-1 strain shows nonreciprocal recombinational events involving long chromosome segments. We also observe greater than expected rates simultaneous different chromosomes both wild-type mutants.
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