Genetics and Causality of Triglyceride-Rich Lipoproteins in Atherosclerotic Cardiovascular Disease

作者: Robert S. Rosenson , Michael H. Davidson , Benjamin J. Hirsh , Sekar Kathiresan , Daniel Gaudet

DOI: 10.1016/J.JACC.2014.09.042

关键词:

摘要: Triglycerides represent 1 component of a heterogeneous pool triglyceride-rich lipoproteins (TGRLs). The reliance on triglycerides or TGRLs as cardiovascular disease (CVD) risk biomarkers prompted investigations into therapies that lower plasma means to reduce CVD events. Genetic studies identified TGRL components and pathways involved in their synthesis metabolism. We advocate only subset genetic mechanisms regulating contribute the This "omic" approach recently resulted new targets for reducing

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