Pyridazine-piperazine compounds and their use as stearoyl-CoA desaturase inhibitors

作者: Vishnumurthy Kodumuru , Nagasree Chakka , Serguei Sviridov , Zaihui Zhang , Vandna Raina

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摘要: Compounds of formula (Ia): where x, y, G, L, M, W, R 2 , 3 5 5a 6 6a 7 7a 8 and 8a are defined herein, disclosed, as well pharmaceutical compositions comprising the compounds. These compounds useful in treating SCD-mediated diseases or conditions.

参考文章(263)
Jordi Frigola-Constansa, David Vaño-Domenech, Jordi Corbera-Arjona, Derivatives of acyl-piperazinil-pyrimidins, preparation thereof and application as medicaments ,(1998)
Gunter Linz, Frank Himmelsbach, Brian Guth, Johannes Weisenberger, Thomas Muller, Helmut Pieper, Volkhard Austel, 5-membered heterocycles, processes for preparing them and pharmaceutical compositions containing these compounds ,(1994)
R. Jeffcoat, A.T. James, Chapter 4 The regulation of desaturation and elongation of fatty acids in mammals New Comprehensive Biochemistry. ,vol. 7, pp. 85- 112 ,(1984) , 10.1016/S0167-7306(08)60122-2
Robert G. Shepherd, Mila T. Du, Antiatherosclerotic 1-piperazinecarbonyl compounds ,(1982)
Erich Dipl-Chem Dr Mueller, Walter Dr Haarmann, Berthold Dipl-Chem Dr Narr, Josef Dipl-Chem Dr Roch, 2,4, (opt.5-), 6-substd. pyriminidines as antithrombic agents - e.g. 6-methyl-5-nitro-2-piperazino-4-thiomorpolino-pyrimidine ,(1973)
José Ignacio Andrés-Gil, Frederik Dirk Deroose, Davy Petrus Franciscus Maria Petit, Rosa Maria Alvarez Escobar, Maria Encarnacion Matesanz-Ballesteros, Eddy Jean Edgard Freyne, 4,5-dihydro-isoxazole derivatives and their pharmaceutical use ,(1999)
Kevin Michael Foote, Craig Samuel Donald, Michael Howard Block, Paul Schofield, Carbazole derivatives and their use as neuropeptide y5 receptor ligands ,(2001)
Robert Narquizian, Synese Jolidon, Roger David Norcross, Henri Stalder, Emmanuel Pinard, Matthias Heinrich Nettekoven, Benzoyl-piperazine derivatives ,(2004)