Evaluation of 11 ionic liquids as potential extraction solvents for benzodiazepines from whole blood using liquid-liquid microextraction combined with LC-MS/MS

摘要: Abstract Ionic liquids (ILs) are becoming a trending topic in sample preparation technology, due to their low volatility, flammability and tunable physiochemical properties. The latter affords the opportunity for creating task-specific solvents. In toxicology, these tailored ILs were not introduced yet; however, they can be significant drug extraction purposes. This study screens 11 commercially available as potential media benzodiazepines from blood samples via liquid-liquid microextraction, coupled liquid chromatography – tandem mass spectrometry (LC-MS/MS). Structure-extraction relationships deducted recovery matrix effect results (n = 5), allowing us devise some of favorable features IL benzodiazepine extraction. Overall, long alkyl chains avoided, may sterically hinder desirable π-stacking interactions. For same reason, aromatic planar cations, imidazolium pyridinium, more effective comparison with ammonium pyrrolidinium. Furthermore, viscosity negatively impacted both recoveries effects. High viscosities limited transfer during dispersion impeded electrospray ionization processes. conclusion, this evaluates which physicochemical an should possess efficiently extract whole blood.