Tear Proteases and Protease Inhibitors: Potential Biomarkers and Disease Drivers in Ocular Surface Disease.

摘要: Tears are highly concentrated in proteins relative to other biofluids, and a notable fraction of tear proteases protease inhibitors. These components present delicate equilibrium that maintains ocular surface homeostasis response physiological temporal cues. Dysregulation the activity inhibitors tears occurs diseases including dry eye infection, conditions wound healing after refractive surgery contact lens (CL) wear. Measurement these changes can provide general information regarding health and, increasingly, has potential give specific clues disease diagnosis guidance for treatment. Here, we review three major categories (matrix metalloproteinases, cathepsins, plasminogen activators [PAs]) their endogenous (tissue cystatins, PA inhibitors), factors associated with eye, infection allergy, surgery, CLs. We highlight suggestions development protease/protease inhibitor biomarkers this promising field.