Immunology in clinic review series; focus on autoinflammatory diseases: inflammasomes: mechanisms of activation.

摘要: OTHER THEMES PUBLISHED IN THIS IMMUNOLOGY THE CLINIC REVIEW SERIES Allergy, Host Responses, Cancer, Type 1 diabetes and viruses, Metabolic diseases. Summary Initiation of a successful immune response requires working set sensors that detect any noxious agent within the cellular microenvironment molecular platforms process this signal to trigger an appropriate effector response. Pattern recognition receptors can engage different signalling cascades lead proinflammatory gene expression. At same time, transcription-independent events such as activation proteases and/or phagocytosis are also initiated. The inflammasome pathway constitutes platform leads so-called inflammatory caspases, most notably caspase-1, which plays pivotal role in cleavage thus maturation cytokines, but induction pyroptosis, special type cell death. In review we elaborate on currently known complexes with focus mechanism behind their activation. Understanding these mechanisms could provide important information regarding potential nodes might be targeted for therapeutic intervention.