NO-dependent protein nitration: a cell signaling event or an oxidative inflammatory response?

摘要: Tyrosine nitration is becoming increasingly recognized as a prevalent, functionally significant post-translational protein modification that serves an indicator of nitric oxide (z.rad;NO)-mediated oxidative inflammatory reactions. Nitration proteins modulates catalytic activity, cell signaling and cytoskeletal organization. Several reactions mediate nitration, all predominantly depend on z.rad;NO- nitrite-dependent formation nitrogen dioxide, species capable nitrating aromatic amino acids, nucleotides unsaturated fatty acids. Here, we review the mechanisms in vivo how specific tyrosine residues impacts function.