Deleterious effects of mycotoxin combinations involving ochratoxin A.

摘要: Ochratoxin A (OTA) is a nephrotoxic mycotoxin with carcinogenic properties. Its presence was detected in various foodstuffs all over the world but significantly higher frequency and concentrations areas endemic nephropathy (EN). Even though food often contaminated more than one mycotoxin, earlier studies focused on occurrence toxicology of only OTA. Only limited number surveys showed that OTA co-occurs mycotoxins (citrinin-CIT, penicilic acid, fumonisin B1-FB1, aflatoxins-AF) which exert nephrotoxic, or carcinogen-promoting activity. This review summarises findings its co-occurrence mentioned as well experimental data their combined toxicity. Most tested mixtures involving produced additive synergistic effects models suggesting these combinations represent significant health hazard. Special attention should be given to include cancer-promoting mycotoxins.