Developments in cancer immunotherapy.

摘要: Significant advances have been made in the field of cancer immunology and immunotherapy over last three decades. An important step forward was identification human antigens eliciting spontaneous immune responses patients. The most immunogenic known to date belong cancer-testis family antigens, which are proteins expressed various types but not any healthy tissues except germ cells. aim is induce or boost existing tumor-specific response by vaccinating with a relevant antigen together an adjuvant. Immunization adjuvant will strong effective can qualitatively quantitatively improve responses. As selective outgrowth antigen-loss variants due immunoediting vivo may occur during vaccination patients, singular metastatic failure sites disease should be surgically removed tested for expression as antigen-negative (or loss) survived pressure system. At this rather early stage development, offered patients only within carefully monitored clinical trials experienced research teams. In addition, it rewarding include early-stage trials, tumor escape less pronounced.