C60 FULLERENE EFFECT ON THE DYNAMICS OF FATIGUE PROCESSES IN RAT SOLEUS MUSCLE AFTER ISCHEMIA-REPERFUSION

摘要: 43 The purposeful application of bio compatible nanomaterials low toxicity is a relevant problem in modern biotechnology. It assumed that the use nanoparticles will help to solve problems early disease diagnostics and targeted delivery drugs into tissues cells, as well new methods selective therapies. C60 fullerene has prominent position among other potentially effective therapeutic agents [1]. known molecule normalizes cellular metabolism neural processes, increases resistance stress, exhibits antiviral properties, pronounced anti-inflammatory anti-allergic effects, enhances activity enzymes regenerative capacity Finally, its derivatives can be used for treatment cancer [2–4]. readily dissolved organic solvents, yet it practically insoluble water [5]. Poor solubility severely hampers investigation physiological pharmacological effects fullerene. As consequence, number with better polar solvents have been synthesized date [5–6]. Pristine aqueous solution (С60FAS) received by transferring molecules from toluene followed sonication [7–8]. dark brown was identified typical colloid system containing single spherical clusters diameter 2–3 nm or more (depending on concentration water) hydrated state [7–9]. Due nanoscale dimensions, watersoluble pristine penetrate cell membrane [10]. Toxicity major concern fullerene-containing biomedical УДК 546.26.043