Copper‐Based Nanostructured Coatings on Natural Cellulose: Nanocomposites Exhibiting Rapid and Efficient Inhibition of a Multi‐Drug Resistant Wound Pathogen, A. baumannii, and Mammalian Cell Biocompatibility In Vitro

摘要: This paper describes a layer-by-layer (LBL) electrostatic self-assembly process for fabricating highly efficient antimicrobial nanocoatings on natural cellulose substrate. The composite materials comprise chemically modified cotton substrate and layer of sub-5 nm copper-based nanoparticles. LBL involves chemical preconditioning step to impart high negative surface charge the chelation controlled binding cupric ions (Cu2+), followed by reduction yield nanostructured coatings fibers. These model wound dressings exhibit rapid killing multidrug resistant bacterial pathogen, A. baumannii, where an 8-log in growth can be achieved as little 10 min contact. Comparative silver-based nanocoated dressings–a more conventional material–exhibit much lower efficiencies; 5-log baumannii is possible after 24 h exposure times silver nanoparticle-coated substrates. copper nanoparticle–cotton composites described herein also resist leaching species presence buffer, order magnitude higher efficiency using 20 less total metal when compared tests soluble Cu2+. Together these data suggest that have facile properties through may associated with contact killing, not simply due enhanced release ion. biocompatibility copper-cotton toward embryonic fibroblast stem cells vitro suggests their potential new paradigm metal-based care combating pathogenic infections.