A rare population of CD24+ITGB4+Notchhi cells drives tumor propagation in NSCLC and requires Notch3 for self-renewal
作者： Yanyan Zheng , Cecile C de la Cruz , Leanne C Sayles , Chris Alleyne-Chin , Dedeepya Vaka
DOI: 10.1016/J.CCR.2013.05.021
关键词:
摘要: Summary Sustained tumor progression has been attributed to a distinct population of tumor-propagating cells (TPCs). To identify TPCs relevant lung cancer pathogenesis, we investigated functional heterogeneity in isolated from Kras-driven mouse models non-small-cell (NSCLC). CD24 + ITGB4 Notch hi are capable propagating growth both clonogenic and an orthotopic serial transplantation assay. While all four receptors mark TPCs, Notch3 plays nonredundant role cell propagation two human NSCLC. The TPC is enriched after chemotherapy, the gene signature correlates with poor prognosis may provide therapeutic target for
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