miR-183-5p Inhibits Occurrence and Progression of Acute Myeloid Leukemia via Targeting Erbin.
作者： Zhuojun Zheng , Xiao Zheng , Yuandong Zhu , Xiaoyan Gu , Weiying Gu
DOI: 10.1016/J.YMTHE.2019.01.016
关键词:
摘要: Erbin has been shown to have significant effects on the development of solid tumors. However, little is known about its function and regulatory mechanism in hematological malignancies. The biological cell proliferation was measured in vitro in vivo. predicted target validated by dual-luciferase reporter assay rescue experiment. We found that overexpression could inhibit promote differentiation acute myeloid leukemia (AML) cells, whereas depletion enhance block AML cells Besides, miR-183-5p identified as upstream regulator negatively regulated expression. results were confirmed RNA pull-down assay. Furthermore, we Erbin, resulting enhanced via activation RAS/RAF/MEK/ERK PI3K/AKT/FoxO3a pathways. pathways mediated interacting with Grb2. These also experiments All above-mentioned findings indicated miR-183-5p/Erbin signaling pathway might represent a novel prognostic biomarker or therapeutic for treatment AML.
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