Effects of Leptin on Intestinal Ischemia–Reperfusion Injury
作者： Sevgi Buyukbese Sarsu , Bulent Hayri Ozokutan , Mehmet Tarakcioglu , Ibrahim Sarı , Cahit Bağcı
DOI: 10.1007/S12262-013-0836-1
关键词:
摘要: Many clinical conditions such as shock, sepsis, mesenteric thrombosis, necrotizing enterocolitis, and bowel transplantation can cause intestinal ischemia–reperfusion (IR) injury. This study was designed to determine the effects of leptin on IR Thirty rats were divided into three groups, each containing ten rats: group A (IR group), B (treatment C (sham group). After 1 h ischemia, clamp removed in order perform reperfusion. In B, 100 mg/kg administered subcutaneously 30 min before groups C, 0.1 ml physiologic saline injected. A, serum tissue nitric oxide (NO) levels significantly decreased, malondialdehyde increased compared sham (p < 0.05). Histopathologic injury lower A. decreased (p < 0.05), but NO The results present demonstrated that decreases by increasing production, rearranging mucosal blood flow, inhibiting polymorphonuclear leukocyte infiltration.
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