The power of NGS technologies to delineate the genome organization in cancer: from mutations to structural variations and epigenetic alterations

摘要: The development of cancer is characterized by the joined occurrence alterations on different levels—from single nucleotide changes via structural and copy number variations to epigenetic alterations. With advent advanced technologies such as next generation sequencing, we have now tools in hands put some light complex processes recognize systematic patterns that develop throughout progression. combination hypothesis-driven experiments with a system-wide genetic view enables us prove so far not addressable questions influence DNA methylation gene expression or disruption genome homeostasis miRNA patterns. Out this enormous amount information, specific biomarkers for progression been discovered, which pave way new therapeutic strategies. Here, will review status quo integrative genomic approaches, give an overview over power sequencing oncology, outline future perspective. Both sides—clinical well basic research aspects—will be considered.