CE–ESI‐MS for bottom‐up proteomics: Advances in separation, interfacing and applications
作者： Anthonius A.M. Heemskerk , André M. Deelder , Oleg A. Mayboroda
DOI: 10.1002/MAS.21432
关键词:
摘要: With the development of more sensitive hyphenation strategies for capillary electrophoresis-electrospray-mass spectrometry technique has reemerged as with high separation power combined sensitivity in analysis peptides and protein digests. This review will discuss newly developed CE-ESI-MS their application bottom-up proteomics well applications same time span, 2009 to present, using co-axial sheathliquid. Subsequently all separate aspects a method shall be discussed, highlighting certain discussing pros cons various choices. The electrophoresis system is discussed including great potential modeling this migration due simple electrophoretic process. Furthermore, technical are namely; background electrolyte choice, coating chosen loading method. Finally, conclusions an outlook on future developments field by provided.
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