SYRA3 COST Action – Microbeam radiation therapy: Roots and prospects

摘要: Microbeam radiation therapy (MRT) is an irradiation modality for therapeutic purposes which uses arrays of collimated quasi parallel microbeams, each up to 100 μm wide, deliver high doses. Several studies have reported the extraordinary tolerance normal tissues MRT irradiation; conversely, has been shown be highly efficient on tumor growth control. The original and most widely developed application MRT, yet in preclinical phase, consists using spatially fractionated X-ray beams issued from a synchrotron source treatment brain tumors. More recently, tested successful pioneering assays reduce or interrupt seizures models epilepsy. concept also extended proton therapy. development towards its clinical implementation presently driven by EU-supported consortium laboratories 16 countries within COST Action TD1205 (SYRA3). results first SYRA3 workshop "Radiation Therapy with Synchrotron Radiation: Achievements Challenges" held Krakow (Poland) during March 25-26 2014 are summarized this issue overview presented paper. papers reflect multidisciplinary international activities SYRA3. topics covered focus include medical physics aspects, pre-clinical studies, applications, industrial perspective; finally outlook future prospects compact sources microbeams.