Molecular basis of intervertebral disc degeneration.

摘要: Intervertebral disc (IVD) degeneration is a disease of the discs connecting adjoining vertebrae in which structural damage leads to and surrounding area. Degeneration considered be normal process aging, but can accelerate faster than expected or precipitated by other factors. The scientific community has come long way understanding biological basis interpreting lifestyle implications IVD degeneration. Of all diseases intervertebral disc, most common earned much attention due its diversity presentation potential multiorgan involvement. We will provide brief overview anatomic, cellular, molecular structure IVD, delve into cellular pathophysiology then highlight some newest developments stem cell, protein, genetic therapy for