Noninvasive Measurement of Exhaled Nitric Oxide in a Spontaneously Breathing Mouse
作者： SEAN WEICKER , TIMOTHY A. KARACHI , JEREMY A. SCOTT , DAVE G. McCORMACK , SANJAY MEHTA
DOI: 10.1164/AJRCCM.163.5.2007025
关键词:
摘要: Nitric oxide (NO) has been detected in the exhaled gas of animals and humans. In previous work, investigators have used anesthetized, mechanically ventilated to obtain NO (ENO) measurements, which unclear effects on levels ENO does not allow for repeated analysis ENO. We sought measure from a single, spontaneously breathing mouse. The mouse was placed small Plexiglas chamber allowed acclimatize before collected analysis. Under optimal operating conditions flow pressure, mean concentration (Fe NO) 25 mice 10.1 ± 1.0 ppb. maximal variation Fe when repeatedly measured daily individual 2.1 Administration l-NAME, nonselective NOS inhibitor, reduced by 51 6% (p < 0.01). Intraperitoneally administered lipopolysaccharide induced acute lung injury increased 30 7% 0.05). demonstrated that it is possible noninvasively a...
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