Cell- and gene-based approaches to tendon regeneration.

摘要: Repair of rotator cuff tears in experimental models has been significantly improved by the use enhanced biologic approaches, including platelet-rich plasma, bone marrow aspirate, growth factor supplements, and cell- gene-modified cell therapy. Despite added complexity, cell-based therapies form an important part repair, combinations carrier vehicles, factors, implanted cells provide best opportunity for robust repair. Bone marrow–derived mesenchymal stem a stimulus repair flexor tendons, but application not shown universally positive results. The scaffolds such as fibrin, synthetic vehicles gene priming differentiation local anabolic anti-inflammatory impact have both provided essential components tendon tendon-to-bone disruption. Application these research techniques human injury generally limited to autologous concentrate, or aspirates combined with scaffold materials. Cultured progenitor therapy gene-enhanced function yet reached clinical trials humans. Research several animal species indicates that concept gene-primed cells, particularly embryonic effective culture conditions, transduction long-term integrating vectors carrying development conditioned RNA interference resist matrix metalloproteinase degradation, may constitute potential advances This review summarizes provides future directions using composites.