Nuclear YB-1 expression as a negative prognostic marker in nonsmall cell lung cancer.

摘要: The human Y-box binding protein, YB-1, is a multifunctional protein that regulates gene expression. Nuclear expression of YB-1 has been associated with chemoresistance and poor prognosis tumour patients. Representative samples from autopsied material primary tumours 77 patients NSCLC were investigated by immunohistochemistry for subcellular distribution p53, in order to evaluate the prognostic role nuclear YB-1. Cytoplasmic was found all samples, whereas only observed 48%. There no correlation histological classification, clinical parameters or size, stage metastasis status. However, positive showed reduced survival times when compared without Including information about histology mutational status p53 increased value Patients mutations had worst (median 3 months), while best outcome wildtype 15 months). This suggests combined analysis both markers allows better identification subgroups varying prognosis. protien seems be an independent marker.