Hypoxia down-regulates MCP-1 expression: implications for macrophage distribution in tumors
作者： Rupert P. M. Negus , Lynn Turner , Frances Burke , Frances R. Balkwill
DOI: 10.1002/JLB.63.6.758
关键词:
摘要: Monocyte chemoattractant protein 1 (MCP-1) is likely to contribute the macrophage infiltrate in human ovarian carcinomas. Although MCP-1 predominantly expressed by tumor parenchyma, macrophages accumulate at highest density necrotic regions, which are associated with low oxygen tensions. Tumor necrosis factor a (TNF-a) can stimulate production and also present within We have investigated effect of hypoxia both on expression cancer cell lines mono- cyte migration. Hypoxia down-regulated TNF-a- induced mRNA cells. The was mimicked cobalt chloride desferrioxamine, consistent specific oxygen-sensing mechanism. Unlike antioxidants, did not inhibit nuclear kB mobilization. migration response diminished under hypoxic condi- tions. Down-regulation inhibition monocyte indepen- dent effects that may distribution tumors. J. Leukoc. Biol. 63: 758-765; 1998.
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