Transient Receptor Potential (TRP) Channels
作者： Amrita Samanta , Taylor E. T. Hughes , Vera Y. Moiseenkova-Bell
DOI: 10.1007/978-981-10-7757-9_6
关键词:
摘要: Transient Receptor Potential (TRP) channels are evolutionarily conserved integral membrane proteins. The mammalian TRP superfamily of ion consists 28 cation permeable that grouped into six subfamilies based on sequence homology (Fig. 6.1). canonical (TRPC) subfamily is known for containing the founding member channels. vanilloid (TRPV) has been extensively studied due to heat sensitivity its member. melastatin-related (TRPM) includes some few bi-functional channels, which contain functional enzymatic domains. ankyrin (TRPA) a single chemo-nociceptor proposed be target analgesics. mucolipin (TRPML) found primarily in intracellular compartments and were discovered their critical role type IV mucolipidosis (ML-IV). polycystic (TRPP) diverse group proteins implicated autosomal dominant kidney disease (ADPKD). Overall, this involved vast array physiological pathophysiological processes making study these imperative our understanding subcellular biochemistry.
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