Synergistic interaction of two classes of transforming growth factors from murine sarcoma cells.
作者： Mario A. Anzano , Anita B. Roberts , Lois C. Lamb , Michael B. Sporn , Joseph M. Smith
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摘要: Abstract Transforming growth factors (TGFs) isolated from murine sarcoma virus-transformed 3T3 cells have been separated by high-pressure liquid chromatography into two subsets. One subset, called TGFα, competes with epidermal factor (EGF) for receptor sites, whereas the other, TGFβ, does not. TGBβ, purified chromatography, will not induce formation of large colonies in soft agar absence TGFα or EGF. However, combined action either EGF (which themselves are relatively ineffective promoting agar) together TGFβ results a potent synergistic effect, colonies. Chemically modified analogs also potentiate activity to extent that they bind receptor. It is suggested may be an important mediator known effects both and on neoplastic transformation.
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