Effects of early protein malnutrition and environmental stimulation on behavioral and biochemical parameters in rats submitted to the elevated plus-maze test
作者： Roberto O Soares , Luiz M Oliveira , Julio S Marchini , José Antunes-Rodrigues , Lucila LK Elias
DOI: 10.1179/1476830512Y.0000000036
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摘要: AbstractThe objective of this study was to compare the effects tactile/handling stimulation (H) and environmental enrichment (EE) in well-nourished (C – 16% protein) malnourished (M 6% rats tested elevated plus-maze (EPM) at 36 37 days age. The results showed higher exploration open arms EPM M as compared with C animals, well lower index risk assessment behaviors, EE, but not H, reversed alterations produced by malnutrition EPM. Biochemical analysis levels corticosterone when rats. non-stimulated animals presented polyamines hippocampus stimulated ones both diet conditions. It is suggested that anxiety risk-assessment behaviors EPM, corticosterone, can be due activity hypothalamic-pituitary-adrenal axis result early prote...
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