Causal Protein-Signaling Networks Derived from Multiparameter Single-Cell Data

作者: Karen Sachs , Omar Perez , Dana Pe'er , Douglas A Lauffenburger , Garry P Nolan

DOI: 10.1126/SCIENCE.1105809

关键词:

摘要: … Second, because the measurements were on single cells, … (because flow cytometry measures single cells in population), … Western blot) data set; and (iii) a truncated individual-cell data …

参考文章(17)
R. Marais, Y. Light, H.F. Paterson, C.J. Marshall, Ras recruits Raf‐1 to the plasma membrane for activation by tyrosine phosphorylation. The EMBO Journal. ,vol. 14, pp. 3136- 3145 ,(1995) , 10.1002/J.1460-2075.1995.TB07316.X
Omar D. Perez, Garry P. Nolan, Simultaneous measurement of multiple active kinase states using polychromatic flow cytometry Nature Biotechnology. ,vol. 20, pp. 155- 162 ,(2002) , 10.1038/NBT0202-155
M.P. Carroll, W.S. May, Protein kinase C-mediated serine phosphorylation directly activates Raf-1 in murine hematopoietic cells. Journal of Biological Chemistry. ,vol. 269, pp. 1249- 1256 ,(1994) , 10.1016/S0021-9258(17)42250-2
Stephen P. Perfetto, Pratip K. Chattopadhyay, Mario Roederer, Seventeen-colour flow cytometry: unravelling the immune system Nature Reviews Immunology. ,vol. 4, pp. 648- 655 ,(2004) , 10.1038/NRI1416
Jonathan M Irish, Randi Hovland, Peter O Krutzik, Omar D Perez, Øystein Bruserud, Bjørn T Gjertsen, Garry P Nolan, Single Cell Profiling of Potentiated Phospho-Protein Networks in Cancer Cells Cell. ,vol. 118, pp. 217- 228 ,(2004) , 10.1016/J.CELL.2004.06.028
K. Sachs, D. Gifford, T. Jaakkola, P. Sorger, D. A. Lauffenburger, Bayesian network approach to cell signaling pathway modeling. Science Signaling. ,vol. 2002, ,(2002) , 10.1126/STKE.2002.148.PE38
Richard Marais, Yvonne Light, Clive Mason, Hugh Paterson, Michael F Olson, Christopher J Marshall, Requirement of Ras-GTP-Raf Complexes for Activation of Raf-1 by Protein Kinase C Science. ,vol. 280, pp. 109- 112 ,(1998) , 10.1126/SCIENCE.280.5360.109
B. Ason, A high-throughput assay for Tn5 Tnp-induced DNA cleavage Nucleic Acids Research. ,vol. 32, pp. 83- 83 ,(2004) , 10.1093/NAR/GNH080
Mario Roederer, Jason M Brenchley, Michael R Betts, Stephen C De Rosa, Flow cytometric analysis of vaccine responses: how many colors are enough? Clinical Immunology. ,vol. 110, pp. 199- 205 ,(2004) , 10.1016/J.CLIM.2003.11.015