In vivo Brainstem Imaging in Alzheimer's Disease: Potential for Biomarker Development.

摘要: The dearth of effective treatments for Alzheimer's disease (AD) is one the largest public health issues worldwide, costing hundreds billions dollars per year. From a therapeutic standpoint, research efforts to date have met with strikingly little clinical success. One major issue that trials begin after substantial pathological change has occurred, and it increasingly clear most treatment regimens will need be administered earlier in process. In order identify individuals within long preclinical phase AD who are likely progress dementia, improvements required biomarker development. potential area might prove fruitful this regard vivo detection brainstem pathology. known undergo changes very early progressively AD. With an updated harmonized framework, emerging advances neuroimaging technology, leverage knowledge pathology into biomarkers discussed.