BCRP/ ABCG2 in the Placenta: Expression, Function and Regulation
作者： Qingcheng Mao
DOI: 10.1007/S11095-008-9537-Z
关键词:
摘要: Knowledge concerning transport of maternally administered drugs across the placental barrier is essential for determining potential toxicity to fetus and value drug therapy during pregnancy. An important determinant fetal exposure expression efflux transporters in placenta. Among human tissues, ATP-binding cassette transporter BCRP (gene symbol ABCG2) most abundantly expressed apical membrane syncytiotrophoblasts. Although precise physiological role placenta still unclear, existing data strongly suggest that plays an protecting against drugs, xenobiotics, metabolites by expelling them barrier. In this review, we summarize current knowledge with respect expression, function, polymorphisms BCRP, as well transcriptional posttranscriptional regulation Finally, clinical significance pregnant women discussed.
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D P McDonnell, P H Giangrande, The A and B isoforms of the human progesterone receptor: two functionally different transcription factors encoded by a single gene. Recent Progress in Hormone Research. ,vol. 54, pp. 291- 314 ,(1999)
Margaret C. Neville, Thomas B. McFadden, Isabel Forsyth, Hormonal regulation of mammary differentiation and milk secretion. Journal of Mammary Gland Biology and Neoplasia. ,vol. 7, pp. 49- 66 ,(2002) , 10.1023/A:1015770423167
Tito Fojo, Lyn Mickley, Susan E. Bates, Mariafiorella Brangi, Barbara Cristensen, Robert Robey, Michael Dean, Keisuke Miyake, Zhirong Zhan, Thomas Litman, Lee Greenberger, Molecular cloning of cDNAs which are highly overexpressed in mitoxantrone-resistant cells: demonstration of homology to ABC transport genes. Cancer Research. ,vol. 59, pp. 8- 13 ,(1999)
Lucy S Hodge, Timothy S Tracy, Alterations in drug disposition during pregnancy Expert Opinion on Drug Metabolism & Toxicology. ,vol. 3, pp. 557- 571 ,(2007) , 10.1517/17425255.3.4.557
Gary D. Kruh, Susan E. Bates, Martin G. Belinsky, Robert W. Robey, Irina Shchaveleva, Yoshikazu Sugimoto, Zhe Sheng Chen, Douglas D. Ross, Xiao Qin Ren, Transport of methotrexate, methotrexate polyglutamates, and 17β-estradiol 17-(β-D-glucuronide) by ABCG2: Effects of acquired mutations at R482 on methotrexate transport Cancer Research. ,vol. 63, pp. 4048- 4054 ,(2003)
I F Faneyte, A C Pijnenborg, J H Schellens, M Maliepaard, G L Scheffer, M J van De Vijver, A H Schinkel, R J Scheper, M A van Gastelen, Subcellular localization and distribution of the breast cancer resistance protein transporter in normal human tissues. Cancer Research. ,vol. 61, pp. 3458- 3464 ,(2001)
Yasumasa Honjo, Kuniaki Morisaki, Lyn Mickley Huff, Robert W. Robey, Jeffrey Hung, Michael Dean, Susan E. Bates, Single-nucleotide polymorphism (SNP) analysis in the ABC half-transporter ABCG2 (MXR/BCRP/ABCP1). Cancer Biology & Therapy. ,vol. 1, pp. 696- 702 ,(2002) , 10.4161/CBT.322
D. Yeboah, M. Sun, J. Kingdom, D. Baczyk, S.J. Lye, S.G. Matthews, W. Gibb, Expression of breast cancer resistance protein (BCRP/ABCG2) in human placenta throughout gestation and at term before and after labor Canadian Journal of Physiology and Pharmacology. ,vol. 84, pp. 1251- 1258 ,(2006) , 10.1139/Y06-078
Anshul Gupta, Yang Dai, R. Robert Vethanayagam, Mary F. Hebert, Kenneth E. Thummel, Jashvant D. Unadkat, Douglas D. Ross, Qingcheng Mao, Cyclosporin A, tacrolimus and sirolimus are potent inhibitors of the human breast cancer resistance protein (ABCG2) and reverse resistance to mitoxantrone and topotecan. Cancer Chemotherapy and Pharmacology. ,vol. 58, pp. 374- 383 ,(2006) , 10.1007/S00280-005-0173-6
Yuhua Zhang, Gengyin Zhou, Huaiping Wang, Xiaofang Zhang, Fulan Wei, Yongping Cai, Deling Yin, Transcriptional Upregulation of Breast Cancer Resistance Protein by 17β-Estradiol in ERα-Positive MCF-7 Breast Cancer Cells Oncology. ,vol. 71, pp. 446- 455 ,(2006) , 10.1159/000108594