Effects of extracellular ATP on the physiology of Streptomyces coelicolor A3(2).
作者： Ming Li , Tae-Jong Kim , Hyung-Jin Kwon , Joo-Won Suh
DOI: 10.1111/J.1574-6968.2008.01248.X
关键词:
摘要: Because ATP is an extracellular effector in animal and plant systems derivatives of ATP, such as S-adenosylmethionine cAMP, can control antibiotic production morphological differentiation Streptomyces, we hypothesized that (exATP) also affect physiologies Streptomyces. We found the addition 10 microM exATP to Streptomyces coelicolor A3(2) cultures resulted enhanced actinorhodin undecylprodigiosin on solid medium. However, these phenotypes were reduced by a 10-fold higher concentration (100 microM). Intracellular concentrations modulated response changes exATP. analogs, added at 100-fold lower concentration, affected similarly seen for The promoter activity actII-orf4 indicated transcriptional level production. Results from this study suggest physiology S. careful manipulation may significantly enhance high-yield antibiotics coelicolor.
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