Endogenous cross-talk of fungal metabolites.

摘要: Non-ribosomal peptide synthesis in fungi requires a ready supply of proteogenic and non-proteogenic amino acids which are subsequently incorporated into the nascent non-ribosomal via thiotemplate mechanism catalysed by synthetases. Substrate can be modified prior to or during incorporation peptide, following an early stage acid-containing biosynthetic intermediate. These post-incorporation modifications involve range additional enzymatic activities including but not exclusively, monooxygenases, methyltransferases, epimerases, oxidoreductases glutathione transferases essential effect biosynthesis final peptide. Likewise, polyketide is directly synthase megaenzymes cluster-encoded ancilliary decorating enzymes. Additionally, suite primary metabolites, for example: CoA, acetyl S-adenosylmethionine, glutathione, NADPH, malonyl CoA molecular oxygen, amongst others required synthesis. Clearly these processes must exquisite orchestration facilitate simultaneous different types peptides, polyketides, related metabolites requiring identical similar precursors co-factors. Moreover, near structures many natural products within given family (e.g., ergot alkaloids), along with localization regions conidia) suggests that cross-talk may exist, terms functionality. Finally, we speculate if certain steps involved play role cellular protection environmental adaptation, wonder reactions equivalent importance actual metabolite.