Adipose tissue, metabolic syndrome and polycystic ovary syndrome: from pathophysiology to treatment.

摘要: In the last few years, polycystic ovary syndrome (PCOS) has deserved major attention because it is linked to same cluster of events that promote metabolic syndrome. This review will point out relationships between fat excess, insulin resistance and Adipocytes are actually considered as endocrine cells synthesize release molecules (adipokines) play an endocrine/paracrine role, such adiponectin, atrial natriuretic peptide, leptin, resistin, tumour necrosis factor alpha (TNFα). Metabolic a chronic low-grade inflammatory condition in which adipokines role. Isolated adipocytes from women with PCOS express higher mRNA concentrations some involved cardiovascular risk resistance. However, environmental factors lifestyle role determining appearance phenotypes PCOS. morbid obese PCOS, bariatric surgery decreases bodyweight excess reverses hyperandrogenism sterility. lean or overweight changes combination drugs reducing visceral reverse symptoms signs Promising treatments for seem be sensitizers metformin glitazones.