The mystery of missing heritability: Genetic interactions create phantom heritability.
作者： O. Zuk , E. Hechter , S. R. Sunyaev , E. S. Lander
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摘要: justified, because models with interactions are also consistent observable data; and (iii) under such models, the total heritability may be much smaller thus proportion of explained larger. For example, 80% currently missing for Crohn’s disease could due to genetic interactions, if involves interaction among three pathways. In short, need not directly correspond variants, current estimates significantly inflated by interactions. Finally, we describe a method estimating from isolated populations that is
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