Metastatic breast carcinoma uncovered in an otherwise unremarkable “random colon biopsy”

摘要: Abstract Breast cancer is one of the most devastating cancers afflicting women, being a main cause related death. Approximately 50% these patients have developed regional or distant metastases at time diagnosis; hence, an early diagnosis and surgery with indicated neoadjuvant therapy are crucial in eradicating this disease improving patient survival. A significant percentage patients, even after initial satisfactory tumor removal, still face threat metastatic diseases which could plague wide spectrum body sites such as bones, lungs, central nervous system, liver gastrointestinal tract (mostly upper locations). Colonic anorectal involvement by breast has been less frequently reported disseminated diseases. Typically, presents mass, enteric stenosis, obstruction. Rare cases, however, may not form endoscopically radiologically recognizable lesion, thus be overlooked. Here we report unique case random colon biopsies presenting epigastric pain, whose stomach biopsy showed Helicobacter pylori -associated chronic active gastritis. No colonoscopic lesion was present; microscopic examination "random biopsy" revealed scattered single small clusters cells involving lamina propria colonic mucosa, morphologically immunophenotypically consistent from carcinoma. The clinical presentation histopathology were reviewed compared limited cases literature. We conclude that high levels suspicion alertness essential to identify occult absence grossly appreciable lesion.