Chemical Mechanisms of the Toxicological Properties of Nanomaterials: Generation of Intracellular Reactive Oxygen Species

摘要: As more and nanomaterials with novel physicochemical properties or new functions are created used in different research fields industrial sectors, the scientific public concerns about their toxic effects on human health environment also growing quickly. In past decade, study of toxicological nanomaterials/nanoparticles has formed a field: nanotoxicology. However, most data published relate to phenomena there is less understanding underlying mechanism for nanomaterial-induced toxicity. Nanomaterial-induced reactive oxygen species (ROS) play key role cellular tissue Herein, we classify pathways intracellular ROS production by into 1)the direct generation through nanomaterial-catalyzed free-radical reactions cells, 2)the indirect disturbing inherent biochemical equilibria cells. We discuss chemical mechanisms associated above generation, from viewpoint high reactivity atoms nanosurface. hope aid origin nanotoxicity provide insights material scientists rational design creation safer greener nanomaterials.