DBAIT and uses thereof

摘要: The invention relates to compositions and methods for interfering with the DNA repair of double strand breaks (DSBs). discloses novel double-stranded nucleic acid molecules that act as baits hijack holocomplex enzymes responsible DSB sensing, signaling and/or pathways, in particular non homologous end joining (NHEJ) pathway repair. use these adjuvant be used association a breaking treatment, particularly radiotherapy or chemotherapy, combination pharmaceutically acceptable carrier, an efficient amount introduced tumor cell nuclei order neutralize transiently their capacity trigger death.