CD133+ ovarian cancer stem-like cells promote non-stem cancer cell metastasis via CCL5 induced epithelial-mesenchymal transition

摘要: // Haixia Long 1,* , Tong Xiang Wei Qi 1 Jiani Huang Junying Chen Luhang He Zhiqing Liang 2 Bo Guo Yongsheng Li Rongkai Xie 3 and Zhu 1,4 Institute of Cancer, Xinqiao Hospital, Third Military Medical University, Chongqing, China Department Obstetrics Gynecology, Southwest 4 Biomedical Analysis Center, * These authors contributed equally to this work Correspondence to: Zhu, email: Xie, Keywords : cancer stem like cells, non-cancer chemokine (C-C motif) ligand 5, epithelial-mesenchymal transition, NF-κB Received October 14, 2014 Accepted January 20, 2015 Published February 28, Abstract Cancer cells (CSCs, also called stem-like CSLCs) can function as “seed cells” for tumor recurrence metastasis. Here, we report that, in the presence CD133 + ovarian CSLCs, - non-CSLCs undergo an transition (EMT)-like process display enhanced metastatic capacity vitro vivo . Highly elevated expression 5 (CCL5) its receptors receptor (CCR) 1/3/5 are observed clinical murine tissues from epithelial carcinomas. Mechanistically, paracrine CCL5 CSLCs activates signaling pathway via binding CCR1/3/5, thereby inducing EMT invasion. Taken together, our results redefine potential non-stem provide evidence that targeting CCL5:CCR1/3/5-NF-κB could be effective strategy prevent