Up-regulation of CC chemokine, CCL3L1, and receptors, CCR3, CCR5 in human glioblastoma that promotes cell growth
作者： Jun Kouno , Hisaki Nagai , Takemitsu Nagahata , Masamitsu Onda , Humio Yamaguchi
DOI: 10.1007/S11060-004-9165-3
关键词: CCL13 、 C-C chemokine receptor type 6 、 Chemokine receptor 、 CCL5 、 Biology 、 CCL21 、 CCL15 、 Cancer research 、 CC chemokine receptors 、 CXC chemokine receptors
摘要: Human CC ligand 3-like protein 1 (CCL3L1), a member of the chemokine family, that induces MCP1 and RANTES, exhibits variety proinflammatory activities including chemotaxis, functional proliferative activation leukocytes, lymphocytes macrophages. Its signal is transmitted through transmembrane receptors, CCR1, CCR3 CCR5. To examine gene expression chemokine, CCL3L1, its CCR5, we analyzed tumor tissues from 21 patients with several types primary gliomas. CCR5 exhibited over-expression in 70% (7/10), 60% (6/10), (6/10) glioblastoma, comparison lower frequencies seen lower-grade Transfection CCL3L1-expression vector to glioblastoma cell line enhanced proliferation cells. These data suggest increased chemokine-receptors system involved brain tumorigenesis, especially progression glioblastoma.
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