A compartmentalization model of hepatitis C virus replication: An appropriate distribution of HCV RNA for the effective replication

摘要: Hepatitis C virus (HCV) infection is a major cause of liver disease. Ten to twenty percent chronic hepatitis will develop complications diseases such as cirrhosis and hepatocellular carcinoma. The culture system HCV established by the specific combination between strain host cell. Some chimeras substituting core NS2 into analogous region JFH1 fail effectively replicate. Core gene mainly encodes structural protein virion contributes assembly, while other regions contribute genome replication. balance assembly replication chimera may differ from that reference strain. We construct mathematical model whole process in single infected It revealed this there are two patterns HCV, explosive arrested In replication, can continue exponentially reproduce its progeny. caused effect positive feedback cycle. On hand, stalled after sufficiently long time has passed because depletion RNA HCV. To avoid arrest must be appropriately distributed three distinct functions template for translation viral proteins component particle. When precede replicate suggested some inappropriate distribution these functions.