Tissue-specific actions of antidiabetic thiazolidinediones on the reduced fatty acid oxidation in skeletal muscle and liver of zucker diabetic fatty rats
作者： Tomohiro Ide , Tomoko Nakazawa , Toshiro Mochizuki , Koji Murakami
DOI: 10.1016/S0026-0495(00)80019-0
关键词:
摘要: Fatty acid overload has been proposed as a cause of decreased responsiveness in the major insulin target tissues body such muscle and liver tissue. We therefore investigated fatty oxidation soleus isolated from Zucker diabetic (ZDF) rats treated with thiazolidinediones, new class antidiabetic agents. 74CO2 production [ 14C]palmitic (C16:0) was lower ZDF versus lean ( P
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