Anxiolytic-Like Effect of a Salmon Phospholipopeptidic Complex Composed of Polyunsaturated Fatty Acids and Bioactive Peptides
作者： Nabila Belhaj , Frédéric Desor , Céline Gleizes , Frédéric Denis , Elmira Arab-Tehrany
DOI: 10.3390/MD11114294
关键词:
摘要: A phospholipopeptidic complex obtained by the enzymatic hydrolysis of salmon heads in green conditions; exert anxiolytic-like effects a time and dose-dependent manner, with no affection locomotor activity. This study focused on physico-chemical properties lipidic peptidic fractions from this natural product. The characterization mineral composition, amino acid fatty acids was carried out. Stability nanoemulsions allowed us to realize behavioral conducted four different tests 80 mice. work highlighted dose dependent its various over period 14 days compared conventional anxiolytic. intracellular redox status neural cells evaluated order determine free radicals scavenging potential these products central nervous system (CNS), after mice sacrifice. fraction showed strong property similar results were found for as well fraction. For first time, neuroprotective extracted head. applications anxiety disorders might be relevant, depending doses, used chronicity supplementation.
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Bilkei-Gorzó A, Gyertyán I, Some doubts about the basic concept of hole-board test. Neurobiology (Budapest, Hungary). ,vol. 4, pp. 405- ,(1996)
Toshiro Matsui, Kiyoshi Matsumoto, Antihypertensive peptides from natural resources Lead Molecules from Natural Products - Discovery and New Trends. ,vol. 2, pp. 255- 271 ,(2006) , 10.1016/S1572-557X(05)02015-5
Pierluigi Graziani, Anxiété et troubles anxieux Nathan Université. ,(2003)
William R. Morrison, Lloyd M. Smith, Preparation of fatty acid methyl esters and dimethylacetals from lipids with boron fluoride–methanol Journal of Lipid Research. ,vol. 5, pp. 600- 608 ,(1964) , 10.1016/S0022-2275(20)40190-7
Parris M. Kidd, Omega-3 DHA and EPA for cognition, behavior, and mood : Clinical findings and structural-functional synergies with cell membrane phospholipids Alternative medicine review : a journal of clinical therapeutic. ,vol. 12, pp. 207- 227 ,(2007)
L. Najafian, A.S. Babji, A review of fish-derived antioxidant and antimicrobial peptides: their production, assessment, and applications. Peptides. ,vol. 33, pp. 178- 185 ,(2012) , 10.1016/J.PEPTIDES.2011.11.013
H HE, X CHEN, H WU, C SUN, Y ZHANG, B ZHOU, High throughput and rapid screening of marine protein hydrolysates enriched in peptides with angiotensin-I-converting enzyme inhibitory activity by capillary electrophoresis. Bioresource Technology. ,vol. 98, pp. 3499- 3505 ,(2007) , 10.1016/J.BIORTECH.2006.11.036
Jean Carignan, Pascal Hild, Guy Mevelle, Jacques Morel, Delphine Yeghicheyan, Routine Analyses of Trace Elements in Geological Samples using Flow Injection and Low Pressure On‐Line Liquid Chromatography Coupled to ICP‐MS: A Study of Geochemical Reference Materials BR, DR‐N, UB‐N, AN‐G and GH Geostandards and Geoanalytical Research. ,vol. 25, pp. 187- 198 ,(2001) , 10.1111/J.1751-908X.2001.TB00595.X
Nina Vinot, Mélanie Jouin, Adrien Lhomme-Duchadeuil, Philippe Guesnet, Jean-Marc Alessandri, Fabienne Aujard, Fabien Pifferi, Omega-3 Fatty Acids from Fish Oil Lower Anxiety, Improve Cognitive Functions and Reduce Spontaneous Locomotor Activity in a Non-Human Primate PLoS ONE. ,vol. 6, pp. e20491- ,(2011) , 10.1371/JOURNAL.PONE.0020491
Seiichi HIRATSUKA, Kenji ISHIHARA, Tomoko KITAGAWA, Shun WADA, Hidehiko YOKOGOSHI, Effect of dietary docosahexaenoic acid connecting phospholipids on the lipid peroxidation of the brain in mice. Journal of Nutritional Science and Vitaminology. ,vol. 54, pp. 501- 506 ,(2008) , 10.3177/JNSV.54.501